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  • Multi-Phenol - Citrulline Super Formula
  • 5 out of 5
  • Availability: IN STOCK - Ships in 1-2 business days.
    • Supports Healthy Circulation and Blood Vessel Health*
    • Promotes Healthy Energy and Vitality*
    • Previously called Nitric Oxide Support Formula

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  • Features and Benefits

    Purity's Super Citrulline - Circulation Support Formula is a cutting-edge dietary supplement designed to promote cardiovascular and circulatory wellness by providing 1.5 grams of its key ingredient (Citrulline) along with key cofactors.* This innovative formulation, which was previously known as Purity’s Nitric Oxide Support Formula, is also buttressed by an innovative phyto-nutrient blend containing several superstar antioxidant polyphenols. One of these headlining polyphenols is called OxyPhyte® Grape Seed Powder,shown to boost antioxidant levels in the body, while the other is an evidence based circulatory promoting polyphenol named CareFlow™ Mango extract.* Each ingredient helps support endothelial (blood vessel) health, circulatory health, cardiovascular function and production of nitric oxide.*

    What is Citrulline and Why is Citrulline So Good for You?

    L-citrulline is an amino acid. Citrulline is not used to form proteins in the body like other amino acids. Citrulline is used primarily as a raw material, or "precursor" for L-arginine, an amino acid important for the production of circulation promoting nitric oxide.* So why not just take L-arginine? While L-arginine supplementation is known to promote cardiovascular health in humans, it’s a bulky ingredient, and its sustained use has been shown to provide diminishing returns in terms of benefits. Citrulline, on the other hand, is metabolized differently in the body, and actually provides readily available L-arginine to support blood vessel and circulatory health.* In 2012, a double-blind, randomized, placebo-controlled parallel-group trial of 15 middle-aged men demonstrated that Citrulline is capable of supporting normal healthy flexibility of arteries.*

    Citrulline has also been shown - in a single-blind, placebo-controlled clinical trial on men with an average age of 56 - to promote normal erectile function and sexual performance.* The effective dose in this study was 1.5 grams daily, the amount provided by one serving of Super Citrulline Formula.

    Nitric Oxide - a "Signaling Molecule" in the body for Healthy Circulation

    In 1998 the Nobel Prize in Medicine was awarded to 3 researchers (Furchgott, Ignarro and Murad) for their discoveries related to "nitric oxide as a signaling molecule in the cardiovascular system". Nitric oxide (NO) is a versatile signaling molecule with a wide range of actions, from immune activity to neurotransmission to vascular function. Essential for normal cardiovascular regulation, NO contributes to the process of relaxing blood vessels when it is produced at optimal levels.

    Citrulline Super Formula -- the "Advanced Circulation Support Proprietary Blend" Benefits

    Interestingly, one of the only foods which contains Citrulline is the watermelon seeds, flesh and especially the rinds. In clinical studies, watermelon extracts with concentrated to provide meaningful amounts of L-citrulline have shown an ability to support cardiovascular function. But getting several servings of watermelon daily to support healthy blood vessels can be quite a chore. The Circulation Support Complex Proprietary Blend in Purity's Citrulline Super Formula features an array of health-promoting phytonutrients with antioxidant properties, such as quercetin and kaempferol in the apple and acerola powder extracts. Combined with these phytonutrients, the OxyPhyte® Grape Seed Powder Extract and CareFlow™ Mango extract in this Circulation Blend further promote blood vessel and endothelial health.* Grape seed extract has exhibited an ability to influence healthy nitric oxide production and support already normal blood pressure levels in clinical trials.*

    Super Citrulline Formula is Now Enhanced With CareFlow™

    CareFlow™ is a unique, cutting edge extract of Mango fruit clinically shown to support healthy circulation in small blood vessels.* In a randomized, double-blind pilot study, 100 mg of CareFlow™, (the same amount we include per serving) taken in a single dose, produced a statistically significant improvement in microcirculation. According to the report, the findings suggests the circulation benefits of CareFlow™ result from the blood vessel relaxing effect of nitric oxide.*


    Cormio L, et al. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology 2011: 77(1):120-21.

    Schwedhelm E, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2007; 65:1:51-59.

    Gerstgrasser A, et al. In vitro activation of eNOS by Mangifera indica (Careless™) and determination of an effective dosage in a randomized, double blind, human pilot study on microcirculation. Planta Med. 2016 Mar;82(4):298-304.

    Quality Assurance

    To achieve the highest standard in specifications of finished product, our manufacturer adheres to the highest quality control measures, including: 

    • NSF International GMP Registration
    • Natural Products Association GMP Certified
    • Written Standard Operating Procedures (SOPs) to comply with current Good Manufacturing Practices (GMP) ensuring consistent quality
    • Certificates of Analysis available
    • Organic Processed Product Registration with State of California Department of Health Services - Food & Drug Branch

    235 Certificate of Analysis
  • Product Reviews
  • Product Reviews

    • Healthy products
    • 5 out of 5
    • 08/31/17 9:10
    • JW
    • 65+
    • M
    • Heart Health
    • Canada
    • 5 out of 5
    • 5 out of 5
    • 5 out of 5
    • I love the products and also the friendly and knowledgeable staff @ Purity Products.