The Vitamin D3 Revolution
Vitamin D's influence on key biological functions vital to one's health and
well-being mandates that Vitamin D3 supplementation can no longer be ignored by
individuals striving to achieve and maintain a greater state of health. The
research on this vitamin keeps coming: cardiovascular health, immune support,
bone and joint health, and much more.* This advancement in scientific knowledge
about D3 is especially notable when we consider that we are living in a time of
widespread Vitamin D insufficiency.1 Formulated by John Cannell, MD, Purity’s
Vitamin D complex is a synergistic blend of targeted nutrients to complement
many of Vitamin D3’s health benefits.
Why Dr. Cannell's Advanced D is Best in Class
Advanced D™ provides a powerful dose of cholecalciferol (Vitamin D3) backed
by nutrients that work in tandem with this crucial vitamin to support the health
of numerous systems within the body. At the foundation of its design as an
answer to widespread Vitamin D deficiency are found a set of other nutrients - key cofactors -
added to compliment the physiological actions of D3. Dr Cannell’s Advanced D™
orchestrates combined actions to make sure that optimal influence is present
towards bone, muscle, and metabolic function.*
The Advanced D Difference - Key CoFactors
Vitamin D is a team player inside the human body, relying on proper levels of
other nutrients - key cofactors - to fulfill its potential in supporting several areas of health.
Magnesium is needed by enzymes that metabolize Vitamin D. Magnesium is another
nutrient that may run low in the diet. Low dietary Magnesium can
contribute to lower levels of circulating Vitamin D.
Dr Cannell’s Advanced D™ presents a highly bioavailable form
of the mineral magnesium as Magnesium Citrate. Zinc plays a role in the Vitamin
D receptor, and Boron supports Vitamin D metabolism.* Remarkably, research in
humans has found synergistic action between Vitamins D and K2, showing a
combined effort to enhance bone health and promote cardiovascular wellness.
Working with Vitamin D, Vitamin K2 helps Calcium find its proper place in the
Going Beyond D3
In addition to the powerful dosage of Vitamin D3, Dr. Cannell’s Advanced D
Formula™ delivers a combination of several cutting edge nutritional ingredients
shown to synergistically help promote proper Vitamin D metabolism and
utilization in the body. Science has shown that supplementation with D3 or
Vitamin K2 can promote bone mineral quality and—when these vitamins are taken
together—that K2 can balance the actions of D3 for even better bone health.2
Working in combination with Vitamin D, Vitamin K2 helps keep calcium in the right places, like the bones, and away from the wrong places, like blood
As is the case with Vitamin D, knowledgeable healthcare providers are
starting to learn that contemporary dietary patterns leave much of the
population with insufficient magnesium consumption. Low dietary magnesium may
also contribute to a lower level of circulating Vitamin D—yet another barrier to
conserving an ideal, strong skeletal structure.4 Magnesium is involved in over
300 enzymatic processes in human cells, and Dr. Cannell’s Advanced D Formula™
features Magnesium Citrate because it is a form of the mineral shown to be
advantageous in terms of absorption.5 Magnesium is well known for its
contributions to bone health, neuromuscular function, cardiovascular health, and
many other essentials of whole-body health, while also becoming recognized for
its relation to healthy energy levels and other aspects of a normal
Taurine is an important amino acid found in many organs, being most
concentrated in the heart and the retina of the eye. Taurine is active in muscle
function, as well as in maintaining optimal function of nerve tissue, lending
itself to neurotransmitter balance. Extensive experimental information has been
gathered (from both animal and human studies) in examining the positive,
beneficial relationship between taurine supplementation and cardiovascular
Don't Forget Boron
A British scientist in the late 20th century looked at data from several
countries and realized that joint and bone health are adversely affected by
modern agricultural and food processing practices. Specifically, he was
concerned about lower amounts of the element Boron in our food supply.9, 10 Dr.
Cannell’s Advanced D Formula™ includes FruiteX-B®, a patented boron/calcium
complex that has been shown to support normal Vitamin D metabolism, maintain
joint comfort and flexibility, and promote healthy bones.* Pilot clinical studies
described improvement in Vitamin D status and more freedom of movement—an
expression of joint function—in subjects consuming FruiteX-B®.11
Support for Your Bones and Muscles*
Without adequate Vitamin D intake, the body cannot properly metabolize
Calcium. Vitamin D strengthens bones and also may enhance muscle strength
because of its direct effect on calcium transport in muscles. Because of its
unique interplay with Calcium, Vitamin D can support the health of both of these
important structures. Other ingredients in Dr. Cannell’s Advanced D Formula™
further support the skeletal and muscular systems.*
Powerful Immune Support*
Vitamin D also has an interesting role as a regulator of the immune system.12
D3 has unique immune-modulating properties that can support long-term health and
wellness by supporting innate immunity. For additional support, Dr. Cannell’s
Advanced D Formula™ contains Zinc, another immune-supporting nutrient. The poor
performance of immune cells seen in zinc deficiency emphasizes the importance of
this mineral for good health.13*
Heart and Cardiovascular Support*
Recent research is increasingly pointing towards the importance of Vitamin D
in maintaining healthy heart function, as individuals having a better Vitamin D
status tend to have more healthy function of the cardiovascular system.14 This
D3 premise of Dr. Cannell’s formulation is complimented by the Zinc, Quercetin
and FruiteX-B® functioning as antioxidants, doing their parts in enhancing the
stability of cell membranes throughout the cardiovascular system.15*
Higher Doses of Vitamin D = Greater Wellbeing Responses
Researchers in Canada observed the effects of Vitamin D3 supplementation in
older adults by comparing a dose of 4000 IU per day to that of only 600 IU
daily. Energy level and mood were measured with wellbeing scores, and the
results were clear—subjects taking the higher doses of D3 had the higher
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ensure that the actual contents of the supplement product match those printed on
Components of the NSF Certification Program
There are three main components of the NSF Dietary Supplements Certification Program:
- Verification that the contents of the supplement actually match what is printed on the label
- Assurance that there are no ingredients present in the supplement that are not openly disclosed on the label
- Assurance that there are no unacceptable levels of contaminants present in the supplement
If you use a dietary supplement that has been certified
by NSF, you can be confident that the contents of your supplement are being
regularly checked by one of the most respected certifiers in the world. With NSF
certification, you get the continued assurance that only NSF’s ongoing testing
programs can provide. Unlike some other programs, NSF conducts annual audits and
periodically retests each dietary supplement product to ensure continued
compliance against the toughest testing standard in existence today.
- Humans make thousands of units of vitamin D within minutes of whole body exposure to sunlight. From what we
know of nature, it is unlikely such a system evolved by chance.
- Whoever wishes to investigate medicine properly should proceed thus: in the first place to consider the seasons
of the year.
- Hippocrates, the father of medicine (circa 400 B.C.).
- Goldstein, D., The epidemic of Vitamin D deficiency. J Pediatr Nurs, 2009. 24(4): p. 345-6.
- Yonemura, K., et al., Protective effect of Vitamins K2 and D3 on prednisolone-induced loss of bone mineral density in the lumbar spine. Am J Kidney Dis, 2004. 43(1): p. 53-60.
- Suttie, J.W., ed. Vitamin K in Health and Disease. 2009, CRC Press - Taylor & Francis Group: Boca Raton, FL. 224.
- Rude, R.K., F.R. Singer, and H.E. Gruber, Skeletal and hormonal effects of magnesium deficiency. J Am Coll Nutr, 2009. 28(2): p. 131-41.
- Lindberg, J.S., et al., Magnesium bioavailability from magnesium citrate and magnesium oxide. J Am Coll Nutr, 1990. 9(1): p. 48-55.
- Musso, C.G., Magnesium metabolism in health and disease. Int Urol Nephrol, 2009. 41(2): p. 357-62.
- Volpe, S.L., Magnesium, the metabolic syndrome, insulin resistance, and type 2 diabetes mellitus. Crit Rev Food Sci Nutr, 2008. 48(3): p. 293-300.
- Xu, Y.J., et al., The potential health benefits of taurine in cardiovascular disease. Exp Clin Cardiol, 2008. 13(2): p. 57-65.
- Newnham, R.E., Agricultural practices affect arthritis. Nutr Health, 1991. 7(2): p. 89-100.
- Newnham, R.E., Essentiality of boron for healthy bones and joints. Environ Health Perspect, 1994. 102 Suppl 7: p. 83-5.
- FruiteX-B. Scientific investigation of FruiteX-B (Calcium fructoborate). 2009 March 4, 2010];
- Cantorna, M.T., et al., Vitamin D status, 1,25-dihydroxyVitamin D3, and the immune system. Am J Clin Nutr, 2004. 80(6 Suppl): p. 1717S-20S.
- Prasad, A.S., Zinc: role in immunity, oxidative stress and chronic inflammation. Curr Opin Clin Nutr Metab Care, 2009.
- Judd, S.E. and V. Tangpricha, Vitamin D deficiency and risk for cardiovascular disease. Am J Med Sci, 2009. 338(1): p. 40-4.
- Scorei, R., et al., In vitro effects of calcium fructoborate on fMLP-stimulated human neutrophil granulocytes. Biol Trace Elem Res, 2007. 118(1): p. 27-37.
- Vieth, R., et al., Randomized comparison of the effects of the Vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients. Nutr J, 2004. 3: p. 8.