• Dr. Cannell's Advanced D
  • Sales Pitch

    • Advanced Bone and Muscle Support*
    • Immune Support*
    • Cardiovascular, Brain and Energy Support*

    Regular Price - $46.95 Volume Pricing Options
    Super Saver - $34.95 ea. - 26% - Learn More
    Buy 4 Get 1 FREE - 4 at $46.95 ea. Plus 1 FREE
  • Details

    As heard on the radio... Formulated by the Executive Director of the Vitamin D Council, Dr. John J. Cannell, Advanced D is a next generation vitamin D complex which includes patented Super Boron, vitamin K2, zinc, and magnesium.

  • Package Description:
    60 Veg. Caps
    Serving Size:
    2 Capsules
    Number of Servings:
    IN STOCK (USA Only)
    Leaves warehouse
    in 1-2 business days.
    • The Vitamin D3 Revolution

      Vitamin D's influence on key biological functions vital to one's health and well-being mandates that Vitamin D3 supplementation can no longer be ignored by individuals striving to achieve and maintain a greater state of health. The research on this vitamin keeps coming: cardiovascular health, immune support, bone and joint health, and much more.* This advancement in scientific knowledge about D3 is especially notable when we consider that we are living in a time of widespread Vitamin D insufficiency.1 Formulated by John Cannell, MD, Purity’s Vitamin D complex is a synergistic blend of targeted nutrients to complement many of Vitamin D3’s health benefits.

      Why Dr. Cannell's Advanced D is Best in Class

      Advanced D™ provides a powerful dose of cholecalciferol (Vitamin D3) backed by nutrients that work in tandem with this crucial vitamin to support the health of numerous systems within the body. At the foundation of its design as an answer to widespread Vitamin D deficiency are found a set of other nutrients - key cofactors - added to compliment the physiological actions of D3. Dr Cannell’s Advanced D™ orchestrates combined actions to make sure that optimal influence is present towards bone, muscle, and metabolic function.*

      The Advanced D Difference - Key CoFactors

      Vitamin D is a team player inside the human body, relying on proper levels of other nutrients - key cofactors - to fulfill its potential in supporting several areas of health. Magnesium is needed by enzymes that metabolize Vitamin D. Magnesium is another nutrient that may run low in the diet. Low dietary Magnesium can contribute to lower levels of circulating Vitamin D.

      Dr Cannell’s Advanced D™ presents a highly bioavailable form of the mineral magnesium as Magnesium Citrate. Zinc plays a role in the Vitamin D receptor, and Boron supports Vitamin D metabolism.* Remarkably, research in humans has found synergistic action between Vitamins D and K2, showing a combined effort to enhance bone health and promote cardiovascular wellness. Working with Vitamin D, Vitamin K2 helps Calcium find its proper place in the body.*

      Going Beyond D3

      In addition to the powerful dosage of Vitamin D3, Dr. Cannell’s Advanced D Formula™ delivers a combination of several cutting edge nutritional ingredients shown to synergistically help promote proper Vitamin D metabolism and utilization in the body. Science has shown that supplementation with D3 or Vitamin K2 can promote bone mineral quality and—when these vitamins are taken together—that K2 can balance the actions of D3 for even better bone health.2 Working in combination with Vitamin D, Vitamin K2 helps keep calcium in the right places, like the bones, and away from the wrong places, like blood vessel walls.*3

      Magnesium Citrate

      As is the case with Vitamin D, knowledgeable healthcare providers are starting to learn that contemporary dietary patterns leave much of the population with insufficient magnesium consumption. Low dietary magnesium may also contribute to a lower level of circulating Vitamin D—yet another barrier to conserving an ideal, strong skeletal structure.4 Magnesium is involved in over 300 enzymatic processes in human cells, and Dr. Cannell’s Advanced D Formula™ features Magnesium Citrate because it is a form of the mineral shown to be advantageous in terms of absorption.5 Magnesium is well known for its contributions to bone health, neuromuscular function, cardiovascular health, and many other essentials of whole-body health, while also becoming recognized for its relation to healthy energy levels and other aspects of a normal metabolism.6, 7*


      Taurine is an important amino acid found in many organs, being most concentrated in the heart and the retina of the eye. Taurine is active in muscle function, as well as in maintaining optimal function of nerve tissue, lending itself to neurotransmitter balance. Extensive experimental information has been gathered (from both animal and human studies) in examining the positive, beneficial relationship between taurine supplementation and cardiovascular health.8*

      Don't Forget Boron

      A British scientist in the late 20th century looked at data from several countries and realized that joint and bone health are adversely affected by modern agricultural and food processing practices. Specifically, he was concerned about lower amounts of the element Boron in our food supply.9, 10 Dr. Cannell’s Advanced D Formula™ includes FruiteX-B®, a patented boron/calcium complex that has been shown to support normal Vitamin D metabolism, maintain joint comfort and flexibility, and promote healthy bones.* Pilot clinical studies described improvement in Vitamin D status and more freedom of movement—an expression of joint function—in subjects consuming FruiteX-B®.11

      Support for Your Bones and Muscles*

      Without adequate Vitamin D intake, the body cannot properly metabolize Calcium. Vitamin D strengthens bones and also may enhance muscle strength because of its direct effect on calcium transport in muscles. Because of its unique interplay with Calcium, Vitamin D can support the health of both of these important structures. Other ingredients in Dr. Cannell’s Advanced D Formula™ further support the skeletal and muscular systems.*

      Powerful Immune Support*

      Vitamin D also has an interesting role as a regulator of the immune system.12 D3 has unique immune-modulating properties that can support long-term health and wellness by supporting innate immunity. For additional support, Dr. Cannell’s Advanced D Formula™ contains Zinc, another immune-supporting nutrient. The poor performance of immune cells seen in zinc deficiency emphasizes the importance of this mineral for good health.13*

      Heart and Cardiovascular Support*

      Recent research is increasingly pointing towards the importance of Vitamin D in maintaining healthy heart function, as individuals having a better Vitamin D status tend to have more healthy function of the cardiovascular system.14 This D3 premise of Dr. Cannell’s formulation is complimented by the Zinc, Quercetin and FruiteX-B® functioning as antioxidants, doing their parts in enhancing the stability of cell membranes throughout the cardiovascular system.15*

      Higher Doses of Vitamin D = Greater Wellbeing Responses

      Researchers in Canada observed the effects of Vitamin D3 supplementation in older adults by comparing a dose of 4000 IU per day to that of only 600 IU daily. Energy level and mood were measured with wellbeing scores, and the results were clear—subjects taking the higher doses of D3 had the higher wellbeing scores.16

      3rd Party Tested and Certified by the NSF

      Truth In Labeling -- A Truly Independent Program

      NSF is an independent, not-for-profit testing organization offering true product testing of dietary supplements. NSF does not simply evaluate test data submitted by manufacturers or analyze just a single sample of a product and give it an okay. They conduct product testing in their own accredited laboratories to ensure that the actual contents of the supplement product match those printed on the label.

      Components of the NSF Certification Program

      There are three main components of the NSF Dietary Supplements Certification Program:

      • Verification that the contents of the supplement actually match what is printed on the label
      • Assurance that there are no ingredients present in the supplement that are not openly disclosed on the label
      • Assurance that there are no unacceptable levels of contaminants present in the supplement

      Consumer Benefits

      If you use a dietary supplement that has been certified by NSF, you can be confident that the contents of your supplement are being regularly checked by one of the most respected certifiers in the world. With NSF certification, you get the continued assurance that only NSF’s ongoing testing programs can provide. Unlike some other programs, NSF conducts annual audits and periodically retests each dietary supplement product to ensure continued compliance against the toughest testing standard in existence today.

      • Humans make thousands of units of vitamin D within minutes of whole body exposure to sunlight. From what we
        know of nature, it is unlikely such a system evolved by chance.

      • Whoever wishes to investigate medicine properly should proceed thus: in the first place to consider the seasons
        of the year.
        • Hippocrates, the father of medicine (circa 400 B.C.).


      1. Goldstein, D., The epidemic of Vitamin D deficiency. J Pediatr Nurs, 2009. 24(4): p. 345-6.
      2. Yonemura, K., et al., Protective effect of Vitamins K2 and D3 on prednisolone-induced loss of bone mineral density in the lumbar spine. Am J Kidney Dis, 2004. 43(1): p. 53-60.
      3. Suttie, J.W., ed. Vitamin K in Health and Disease. 2009, CRC Press - Taylor & Francis Group: Boca Raton, FL. 224.
      4. Rude, R.K., F.R. Singer, and H.E. Gruber, Skeletal and hormonal effects of magnesium deficiency. J Am Coll Nutr, 2009. 28(2): p. 131-41.
      5. Lindberg, J.S., et al., Magnesium bioavailability from magnesium citrate and magnesium oxide. J Am Coll Nutr, 1990. 9(1): p. 48-55.
      6. Musso, C.G., Magnesium metabolism in health and disease. Int Urol Nephrol, 2009. 41(2): p. 357-62.
      7. Volpe, S.L., Magnesium, the metabolic syndrome, insulin resistance, and type 2 diabetes mellitus. Crit Rev Food Sci Nutr, 2008. 48(3): p. 293-300.
      8. Xu, Y.J., et al., The potential health benefits of taurine in cardiovascular disease. Exp Clin Cardiol, 2008. 13(2): p. 57-65.
      9. Newnham, R.E., Agricultural practices affect arthritis. Nutr Health, 1991. 7(2): p. 89-100.
      10. Newnham, R.E., Essentiality of boron for healthy bones and joints. Environ Health Perspect, 1994. 102 Suppl 7: p. 83-5.
      11. FruiteX-B. Scientific investigation of FruiteX-B (Calcium fructoborate). 2009 March 4, 2010];
      12. Cantorna, M.T., et al., Vitamin D status, 1,25-dihydroxyVitamin D3, and the immune system. Am J Clin Nutr, 2004. 80(6 Suppl): p. 1717S-20S.
      13. Prasad, A.S., Zinc: role in immunity, oxidative stress and chronic inflammation. Curr Opin Clin Nutr Metab Care, 2009.
      14. Judd, S.E. and V. Tangpricha, Vitamin D deficiency and risk for cardiovascular disease. Am J Med Sci, 2009. 338(1): p. 40-4.
      15. Scorei, R., et al., In vitro effects of calcium fructoborate on fMLP-stimulated human neutrophil granulocytes. Biol Trace Elem Res, 2007. 118(1): p. 27-37.
      16. Vieth, R., et al., Randomized comparison of the effects of the Vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients. Nutr J, 2004. 3: p. 8.

    • Product Reviews

      • Advanced D Difference!
      • 5 out of 5
      • 05/15/11 11:02
      • Robin2381
      • 55 to 64
      • Female
      • General Health
      • Arizona
      • 5 out of 5
      • 4 out of 5
      • 5 out of 5
      • After reading the peer reviewed literature I tried this product; amazing that we often don't know what we are missing, until we find it! Clearly a difference in overall general health; feel more 'settled'; more energy...recommended!
      • I love my Advanced D
      • 5 out of 5
      • 05/17/11 10:55
      • John in Ohio
      • 55 to 64
      • Male
      • Energy
      • Marietta, OH
      • 5 out of 5
      • 5 out of 5
      • 5 out of 5
      • As a road warrior (I travel a lot) I heard the discussion about Advanced D on my car radio. I was tired, stressed and thought the free 30 day supply sounded worth trying so I pulled over and wrote down the phone number. One thing that appealed to me was the doctor's belief that they were willing to give it away because they felt that anyone trying it would experience the benefits and want to continue.

        My personal experience was pretty dramatic. I took my Advanced D along with their Fish Oil which was recommended to do together. Shortly afterwards I remember saying "whoa what is going on?" Energy, clarity and calmness just seemed to rush in. I've been taking them now for several months and I know I will continue for my lifetime.

        My mind is sharper than it's been in decades. Yet with the sharpness comes a calmness that helps me concentrate even more. In other words I could drink a lot of coffee and have half the sharpness along with a bunch of nervousness or I can take Advanced D along with their Fish Oil and experience a whole new level of energy, mental sharpness and a sense of peace.

        I never write reviews but I chose to write this one because if someone out there is tired and under a lot of pressure at work they may identify with my story and give it a try. Then I will have helped someone as well.
      • Well worth the money
      • 5 out of 5
      • 05/25/11 2:07
      • Sister W
      • 65+
      • Female
      • Fitness
      • Utah
      • 5 out of 5
      • 5 out of 5
      • 5 out of 5
      • My husband and I have taken Dr. Cannells Advanced D formula for the past three years and have been able to meet the Vitamin D level required by our Family Doctor. We also take the Omega Three formula as well as the Ultimate H.A. and find our well being is much improved. We are 75 year old average Senior Citizens making the best of our advanced years.
      • Doctor Remarked on Lab Results
      • 5 out of 5
      • 08/24/11 11:47
      • Kay B
      • 65+
      • Female
      • Joint Health
      • Southern California
      • 5 out of 5
      • 5 out of 5
      • 5 out of 5
      • At my last Dr. appt., my doctor remarked about my Vitamin D results. "Excellent" "What do you take?"
        I told her it was Dr. Cannell's Advanced D from
        Purity Products. I was very pleased because I was
        feeling better, too.
      • 5 out of 5
      • 10/12/11 11:54
      • hammerhead
      • 65+
      • Male
      • Brain, Mood, and Memory
      • ALABAMA
      • 5 out of 5
      • 5 out of 5
      • 5 out of 5
      1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Next >>

      To meet established specifications for dietary supplements, our manufacturer adheres to the highest quality control standards, including:

      • NSF International GMP Registration
      • Health Canada GMP Certified
      • Written Standard Operating Procedures (SOPs) to comply with current Good Manufacturing Practice (cGMP) for dietary supplements, in accordance with 21 CFR Part 111
      • Finished products that meet or exceed United States Pharmacopeia (USP37/NF32) specifications
      • Certificates of Analysis available
      • VCP (Vendor Certification Program) to ensure raw material quality
      • Compliance with the Public Health Security and Bioterrorism Preparedness and Response Act of 2002

      235 Certificate of Analysis
  • You May Also Like:

    • Ultra-Pure Omega-3 Fish Oil with LemonLock™
    • Our concentrated molecularly distilled Ultra-Pure Omega-3 Fish Oil is recognized for its positive role in the health of the heart, brain, and more.*
    • Dr. Cannell's Advanced D without Vitamin K
    • Formulated by the Executive Director of the Vitamin D Council, Dr. John J. Cannell, Advanced D is a next generation vitamin D complex which includes patented Super Boron, zinc, and magnesium, now available without Vitamin K2.
    • Perfect Multi Super Greens®
    • Experience the benefits of our most cutting edge multivitamin, the Perfect Multi Super Greens. Featuring over 60 ingredients, including the essential vitamins, minerals, plus super foods to support energy, focus, immunity, cardio health and vitality.*

Order Line (24 Hr): 1-800-256-6102 Customer Care: 1-888-769-7873
Customer Care Hours: Mon-Thu 9am-9pm ET,
Fri 9am-7pm ET, Sat 9am-5pm ET
200 Terminal Drive, Plainview, NY 11803
© 2015 Purity Products

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Order Line (24 Hr): 1-800-256-6102 Customer Care: 1-888-769-7873
Customer Care Hours: Mon-Thu 9am-9pm ET,
Fri 9am-7pm ET, Sat 9am-5pm ET
200 Terminal Drive, Plainview, NY 11803
© 2015 Purity Products

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.